SigClinical
Every recommendation,
cited to its section.
15,497 recommendations from 384 guidelines and labels, 142 conditions, and 3,609 dose rules. Each one names the document it came from.
Conditions and guidelines
Fifteen specialties of guidelines, read to the recommendation.
Sig doesn’t boil a guideline down to a paragraph. Each recommendation is its own row, with the population it covers and the section it came from. Heart failure alone carries the 2022 AHA/ACC/HFSA guideline and the 2024 ACC pathway, row by row, beside the drugs, calculators, and trees for the condition.
Dose Adjustment
Enter the labs once. Check the whole list.
Creatinine, liver function, weight, age, and the other drugs on board, checked against every medication on the list in one pass. Each flag names the label or guideline behind it, and the adjusted dose sits beside the source.
Antibiotic Selection
From the syndrome to the narrowest drug that works.
Empiric therapy by syndrome, targeted therapy from the culture, then IV-to-PO and de-escalation, checked against allergy, renal function, pregnancy, and QT. Enter your institution’s antibiogram and it overrides the national defaults.
Calculators
1,000+ calculators. Each one shows the math.
Cockcroft-Gault, Child-Pugh, MELD 3.0, HAS-BLED, Wells, PREVENT, and the rest of 30 categories. The inputs, the result, the method, and its limitations stay on one screen, with the disease states it relates to.
Drugs
Monographs written for the questions you actually get.
Every form and strength with what the tablet looks like and who makes it, renal and hepatic dosing, whether it can be crushed, and what to tell the patient. Every other drug opens from its current FDA label, with a button to its Orange Book or Purple Book entry.
Questions
Asked and answered.
Does Sig adjust doses for kidney and liver function?
Yes. Pharmacists using Sig's Dose Adjustment tool check a whole medication list against kidney and liver function, weight, age, labs, and interacting drugs in one pass. As of November 3, 2026, our data hold 3,609 rules for 405 drugs. Each flag names the source FDA label or guideline beside the adjusted dose.
Clinical values entered in the tool are held in memory and discarded on leaving the tool. The app never sends the values anywhere.
For example, for a 78-year-old man weighing 62 kg with a serum creatinine of 2.2 mg/dL, Sig calculates a Cockcroft-Gault creatinine clearance (Cockcroft 1976) of 24 mL/min. Sig then flags gabapentin: reduce to approximately 200 to 700 mg once daily, the band for creatinine clearance from 15 to below 30 mL/min, according to the Dosage and Administration section of the FDA label.
Additionally, the flag lists what to monitor and the date the rule was last reviewed.
Can Sig help choose an antibiotic?
Yes. Sig's Antibiotic Selection tool suggests empiric therapy for 72 infection syndromes, targeted therapy from a culture result, and IV-to-PO and de-escalation options. Each option is checked against allergy, renal function, pregnancy, and QT. An institution's antibiogram, entered on the device, overrides the national defaults.
Additionally, 1,647 susceptibility breakpoints and 88 expert rules cover 121 organisms. The Antimicrobial Spectrum tool shows preferred, alternative, and limited-utility agents by organism or by drug.
Our data cover 72 syndromes and 42 pathogen-directed entries, last updated October 22, 2026.
For example, with an Escherichia coli blood culture, Sig asks whether the laboratory reports by CLSI or EUCAST breakpoints and whether the infection is deep-seated, then lists organism-directed options. The organism page also carries laboratory caveats, such as the FDA clearance note on the Verigene BC-GN panel, which does not distinguish E. coli from Shigella species.
Which clinical calculators does Sig include?
Sig's calculator library is a set of more than 1,000 clinical calculators in 30 categories. For example: Cockcroft-Gault creatinine clearance (Cockcroft 1976), Child-Pugh, MELD 3.0 (Kim 2021), HAS-BLED (Pisters 2010), Wells criteria for PE and DVT, qSOFA, and the AHA PREVENT equations. Each result shows the inputs, the formula, and the citation on one screen.
Every calculator in the count has a working engine in the app. Our data show 1,013 of the 1,183 catalog entries (86%) have an engine, as of November 3, 2026. Additionally, entries without an engine are not counted, which is why the published number is lower than the catalog size.
A result can be shared through Apple's share sheet as text with the inputs, or as a link to get-sig.app opening the same calculator. Calculator inputs are held in memory on the device while the calculator is open and are discarded on closing.
Who writes and reviews Sig's clinical content?
Sig's content is written by a Doctor of Pharmacy and reviewed by two additional Pharm.D. reviewers. Every item a named reviewer has not yet cleared is labeled In Development in the app. Every data set shows the date of last review, so review status is visible rather than assumed.
Sig will be published only once the author is a registered pharmacist. A named reviewer roster and a public corrections log are part of the launch plan.
Our data show that 384 of the 384 guideline records (100%) still carry the In Development label while review continues, as of November 3, 2026.
For example, a dose rule a reviewer has not yet cleared shows In Development beside the rule, and the About and Sources screen lists each data set with a review date. Additionally, content corrections reported through Report a Problem are checked against the cited source before any fix.
What does "In Development" mean in Sig?
In Development means the item has been written and cited, but a named pharmacist reviewer has not yet cleared the item. The label is a signal to apply more of one's own scrutiny, not a statement the content is wrong. Sig shows review state openly, so a pharmacist can tell which parts have had a second review.
For example, a newly added guideline recommendation carries the In Development label until a named Pharm.D. reviewer checks the quote against the source document and clears the recommendation. Additionally, the About and Sources screen shows when each data set was last reviewed.
Our data show that 384 of the 384 guideline records (100%) carry the label today, as of November 3, 2026. Review is still in progress, and the label comes off an item only when a named reviewer clears the item.
Be in the first build.
Sig opens as a TestFlight beta before it reaches the App Store. One email is the whole sign-up: no account, no marketing list.